Aiming at the problem that thermal comfort prediction, which is a complicated nonlinear process, can not be applied to real-time control of air conditioning directly, this paper proposed a thermal comfort prediction model based on the improved Particle Swarm Optimization-Back Propagation (PSO-BP) neural network algorithm. By using PSO algorithm to optimize initial weights and thresholds of BP neural network, the problem that traditional BP algorithm converges slowly and is sensitive to the initial value of the network was improved in this prediction model. Meanwhile, for the standard PSO algorithm prone to premature convergence, weak local search capabilities and other shortcomings, this paper put forward some improvement strategies to further enhance the PSO-BP neural network capabilities. The experimental results show that, the thermal comfort prediction model based on the improved PSO-BP neural network algorithm has faster algorithm converges and higher prediction accuracy than the traditional BP model and standard PSO-BP model.